中国研究团队推出自然语言蛋白质设计工具,Hugging Face 同步托管 DNA 层面工具
原标题:Vibe genes? Natural(ish) language comes to protein, genome design software
一个以中国为基地的大型研究团队合作推出可根据自然语言提示词生成具有指定功能蛋白质的工具,但目前成功率不高,需要实验室从中筛选出可用设计;此前用户仍需掌握酶机制、特定氨基酸位置及催化区域水分子等专业知识。另一项公告中,Hugging Face 宣布托管一个可在 DNA 层面做类似工作的工具。
为什么值得看原文介绍了用自然语言提示词设计蛋白质的研究进展,并提到 Hugging Face 托管了可在 DNA 层面做类似工作的工具,为读者提供这一方向的入门线索。
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原文
Protein design tools may be getting increasingly sophisticated, but you still need a sophisticated understanding of protein structure for them to work. This can include knowing enzyme mechanisms down to the positions of specific amino acids, as well as the water molecules that also occupy the area where catalysis takes place. Once you specify these, the tools can build the rest of a protein around this target.
A large collaboration of researchers based in China, however, decided to bring protein design to the masses, making a tool that can take natural language prompts and use them to produce proteins with the function you specify. If your measure for success is a working protein, then the success rate may not be great. But they still manage to get the job done. And, in a separate announcement, Hugging Face shared that it's now hosting a tool that does similar things on the DNA level.
The equivalent of vibe coding may have come to protein design—at least if you have access to a lab where you can sort the good designs from the dozens of failed ones.
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